Effect of treatment on physiological responses to exercise in East African industrial workers with iron deficiency anaemia.

Davies, C. T. M., and van Haaren, J. P. M. (1973). British Journal oflndustrial Medicine, 30, 335-340. Effect of treatment on physiological responses to exercise in East African industrial workers with iron deficiency anaemia. The physiological responses to exercise on an upright bicycle ergometer have been investigated in groups of anaemic (mean Hb-7 8 g/l00 ml) and control (mean Hb = 13 7 g/l00 ml) East African industrial workers before and after treatment with oral iron (Fe 200 mg) tablets and on a third group of anaemic subjects (mean = 74 g/100 ml) who received no treatment. Before treatment anaemic subjects exercised with an increased cardiac frequency at a fixed oxygen intake (Vo2) of 1-5 1/mn and a marked reduction in predicted maximum aerobic power output when compared to normal controls. The effect of therapy was to reverse these changes so that no significant differences existed between the two treatment groups but both were significantly different from their anaemic controls. The pulmonary minute ventilation at a V02 of 1-5 1/min and the Vo2 at a work load of 8 820 Nm/min (900 kpm/min) were similar in all three groups of subjects and remained constant throughout the experimental investigation. The findings carry important implications for those engaged in industrial medicine in developing countries and show clearly that the debilitating effects of iron deficiency anaemia can be rapidly eliminated by simple and inexpensive therapy in factory workers without seriously disturbing their normal work routine.